Get A Systems Biology Approach to Blood PDF

By Seth Joel Corey, Marek Kimmel, Joshua N. Leonard

ISBN-10: 1493920944

ISBN-13: 9781493920945

ISBN-10: 1493920952

ISBN-13: 9781493920952

The blood approach is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood involves circulating cells, mobile fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments end result from a highly-ordered procedure, hematopoiesis. Definitive hematopoiesis happens within the bone marrow, the place pluripotential stem cells supply upward thrust to a number of lineages of hugely really good cells. Highly-productive and constantly regenerative, hematopoiesis calls for a microenvironment of mesenchymal cells and blood vessels.

A platforms Biology method of Blood is split into 3 major sections: simple elements, physiological techniques, and medical purposes. utilizing blood as a window, one could learn future health and ailment via this specific instrument field with reactive organic fluids that mirrors the present hemodynamics of the vessel partitions and a number of the blood cellphone forms. Many blood illnesses, infrequent and customary can and feature been exploited utilizing structures biology methods with winning effects and as a result excellent types for platforms drugs. extra importantly, hematopoiesis bargains the most effective studied platforms with perception into stem mobilephone biology, mobile interplay, improvement; linage programing and reprograming which are each day motivated by means of the main mature and understood regulatory networks.

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35. Krishnamurthy P, Ross DD, Nakanishi T, Bailey-Dell K, Zhou S, Mercer KE, et al. The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J Biol Chem. 2004;279(23):24218–25. 36. Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Takubo K, et al. Tie2/angiopoietin- 1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell. 2004;118(2): 149–61. 37. Thoren LA, Liuba K, Bryder D, Nygren JM, Jensen CT, Qian H, et al. Kit regulates maintenance of quiescent hematopoietic stem cells.

Blood Cells. 1978;4(1–2):7–25. 8. Allen TD, Dexter TM. The essential cells of the hemopoietic microenvironment. Exp Hematol. 1984;12(7):517–21. 2 Quantification and Modeling of Stem Cell– Niche Interaction 33 9. Dexter TM, Wright EG, Krizsa F, Lajtha LG. Regulation of haemopoietic stem cell proliferation in long term bone marrow cultures. Biomedicine. 1977;27(9–10):344–9. 10. Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981;292(5819):154–6.

Besides the multitude of possible modeling techniques, there are some common characteristics for models of the spatiotemporal niche organization. Cell heterogeneity requires representation of the internal state of individual cells. , differentiation/cell cycle position or levels of protein/transcription factors is determined by the experimental context. To 2 Quantification and Modeling of Stem Cell– Niche Interaction 31 pursue understanding of the spatiotemporal organization implies to relate the internal states to dynamic spatial entities.

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A Systems Biology Approach to Blood by Seth Joel Corey, Marek Kimmel, Joshua N. Leonard

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