Download e-book for iPad: Allergy by Fred R.T. Nelson and Carolyn Taliaferro Blauvelt (Auth.)

By Fred R.T. Nelson and Carolyn Taliaferro Blauvelt (Auth.)

ISBN-10: 0723436584

ISBN-13: 9780723436584

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In addition, chemokines play a primary role in promoting chemotaxis of leukocytes into inflamed tissues. 26 Modulation of allergic responses by cytokines, chemokines, and adhesion molecules leukocyte. This change in leukocyte integrin affinity from a low-affinity to a high-affinity integrin binding state leads to tight adherence of the leukocyte to endothelium and subsequent leukocyte extravasation. Once the leukocyte extravasates between endothelial cells into the extracellular space, the chemokine concentration gradient promotes directed cell migration to the site of inflammation.

Affecting gene expression or encoded protein function), or that are selected for maximal information on the basis of linkage disequilibrium patterns surrounding the gene (often termed ‘tagging SNPs’), are then tested for association with the disease or phenotype in question. A hybrid approach is the selection of candidate genes based not only on their function but also on their position within a genetic region previously linked to the disease (positional candidate). However, by definition, the candidate gene approach is not capable of identifying all the major genetic factors predisposing towards a disease or identifying role for novel gene products in disease pathogenesis.

In addition to the predominant expression of CC chemokine receptors, eosinophils, basophils, and mononuclear cells express the CXC chemokine receptor CXCR4, which is also expressed on neutrophils. The ligand for CXCR4 is the CXC chemokine SDF-1 (stromal cell derived factor-1). T-cell subsets and chemokine receptors Although certain chemokine receptors have been associated with specific T-cell subsets, chemokine receptor expression in vivo is complex and overlapping. Examples of chemokine receptors expressed on T-cell subsets include CCR4 and CCR8 on Th2 cells, and CCR5, CXCR3, and CXCR6 on Th1 cells (Fig.

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Allergy by Fred R.T. Nelson and Carolyn Taliaferro Blauvelt (Auth.)

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