By Jennifer M. Carbrey, Peter Agre (auth.), Prof. Dr. Eric Beitz (eds.)
The aquaporin box has matured at an extremely speedy velocity and we're on the verge to advance severe recommendations to therapeutically modulate aquaporin functionality without delay or through regulatory networks. Key necessities can be found this present day: i. a substantial (and starting to be) variety of aquaporin crystal constructions for the rational layout of inhibitory molecules, ii. difficult molecular dynamics simulation concepts for theoretical analyses of selectivity mechanisms and docking experiments, iii. entire info on aquaporin immunohistochemistry, iv. aquaporin knockout animals for physiological stories, and v. assay platforms for compound library screenings. The constitution of this quantity on aquaporins follows the issues laid out above and hence covers the advancements from simple examine to power pharmacological use. positioned among pharmacology textbooks and up to date clinical papers this ebook presents a well timed review for readers from the elemental in addition to the utilized disciplines.
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Am J Physiol 265:F461 Amiry-Moghaddam M, Williamson A, Palomba M, Eid T, de Lanerolle NC, Nagelhus EA, Adams ME, Froehner SC, Agre P, Ottersen OP (2003) Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice. Proc Natl Acad Sci USA 100:13615–13620 Amiry-Moghaddam M, Xue R, Haug FM, Neely JD, Bhardwaj A, Agre P, Adams ME, Froehner SC, Mori S, Ottersen OP (2004) Alpha-syntrophin deletion removes the perivascular but not the endothelial pool of aquaporin-4 at the blood–brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia.
3 Surface Structure of AQPs Involved in Membrane Junctions . . . . . . . . . 4 Unsolved Riddles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 AQP Trafficking . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 AQP Gating . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Anion Transport . . . . . . . . . . .
Proc Natl Acad Sci USA 96:5808–5813 Zeidel ML, Ambudkar SV, Smith BL, Agre P (1992) Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein. Biochemistry 31:7436–7440 Zeidel ML, Nielsen S, Smith BL, Ambudkar SV, Maunsbach AB, Agre P (1994) Ultrastructure, pharmacologic inhibition, and transport-selectivity of aquaporin CHIP in proteoliposomes. Biochemistry 33:1606–1615 Zelenina M, Bondar AA, Zelenin S, Aperia A (2003) Nickel and extracellular acidification inhibit the water permeability of human aquaporin-3 in lung epithelial cells.
Aquaporins by Jennifer M. Carbrey, Peter Agre (auth.), Prof. Dr. Eric Beitz (eds.)